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The International Space Station Research and Development Conference (ISSRDC) brings together leaders from the commercial sector, U.S. government agencies, and academic communities to foster innovation and discovery onboard the International Space Station (ISS). The conference is hosted by the Center for the Advancement of Science in Space, Inc., manager of the ISS National Laboratory; NASA; and the American Astronautical Society (AAS). ISSRDC showcases how the space station continues to provide a valuable platform for research and technology development that benefits humanity and enables a robust and sustainable market in low Earth orbit. Additionally, the ISSRDC marketplace expo allows companies to showcase how they are advancing opportunities in low Earth orbit and provides a venue to meet with researchers, stakeholders, and policymakers.